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Wen Wang, Gang Xu, Cui-Ling Ding, Lan-Juan Zhao, Ping Zhao, Hao Ren and Zhong-Tian Qi All-trans retinoic acid protects hepatocellular carcinoma cells against serum-starvation-induced cell death by upregulating collagen 8A2 FEBS Journal 280

Article first published online: 6 FEB 2013 | DOI: 10.1111/febs.12122

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As a therapeutic agent to various cancers, all-trans retinoic acid (atRA) has been reported to inhibit the growth, induce apoptosis or cause differentiation. In this study, atRA was found to protect HCC cells against serum starvation induced cell death, and COL8A2 was identified as the key protein involved in the enhancement of cell adhesion of atRA under serum free condition

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