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Nicolas Herzog, Jörg D. H. Hartkamp, Patricia Verheugd, Fabian Treude, Alexandra H. Forst, Karla L. H. Feijs, Barbara E. Lippok, Elisabeth Kremmer, Henning Kleine and Bernhard Lüscher Caspase-dependent cleavage of the mono-ADP-ribosyltransferase ARTD10 interferes with its pro-apoptotic function FEBS Journal 280

Article first published online: 13 FEB 2013 | DOI: 10.1111/febs.12124

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Little is known about the cellular functions of ARTD10/PARP10, a mono-ADP-ribosyltransferase. We found that the ectopic expression of ARTD10, but not a catalytically inactive mutant, induces apoptosis. This is accompanied by caspase-mediated cleavage of ARTD10, which inhibits its proapoptotic function. Moreover DNA damage induced apoptosis is repressed when ARTD10 is knocked-down, suggesting a regulatory role of ARTD10 during apoptosis

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