E-mail

E-mail a Wiley Online Library Link

Xinrui Zhou, Kathleen Szeker, Bernd Janocha, Thomas Böhme, Dirk Albrecht, Igor A. Mikhailopulo and Peter Neubauer Recombinant purine nucleoside phosphorylases from thermophiles: preparation, properties and activity towards purine and pyrimidine nucleosides The FEBS Journal 280

Version of Record online: 21 FEB 2013 | DOI: 10.1111/febs.12143

Thumbnail image of graphical abstract

Recombinant purine nucleoside phosphorylases from Deinococcus geothermalis, Geobacillus thermoglucosidasius and Aeropyrum pernix geothermalis were prepared and their thermostability, kinetic properties, substrate specificities towards (deoxy)adenosine, (deoxy)inosine, (deoxy)cytidine and C2′-modified (aminodeoxy, deoxyfluoro) nucleosides investigated. DgPNP and ApMTAP are promising biocatalysts in the synthesis of 9-(2-deoxy-2-fluoro-⁢-D-ribo/arabino-furanosyl)adenines using the corresponding uracil deoxyfluoro nucleosides as the pentofuranose donors in the transglycosylation reaction of adenine

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH