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Thomas Neill, Holly R. Jones, Zoe Crane-Smith, Rick T. Owens, Liliana Schaefer and Renato V. Iozzo Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1 The FEBS Journal 280

Version of Record online: 15 FEB 2013 | DOI: 10.1111/febs.12148

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Upon engaging EGFR, decorin induces transient receptor activation leading to RhoA degradation via the 26S proteasome. This precludes RhoA from stimulating the inhibitory properties of ROCK1 on thrombospondin-1 (TSP-1). Thus, in the presence of decorin, ROCK1 no longer suppresses TSP-1 secretion; hence, there is enhanced movement of TSP-1-containing vesicles to the cell surface for its secretion and consequent angiogenesis inhibition.

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