Thomas Neill, Holly R. Jones, Zoe Crane-Smith, Rick T. Owens, Liliana Schaefer and Renato V. Iozzo Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1 The FEBS Journal 280
Upon engaging EGFR, decorin induces transient receptor activation leading to RhoA degradation via the 26S proteasome. This precludes RhoA from stimulating the inhibitory properties of ROCK1 on thrombospondin-1 (TSP-1). Thus, in the presence of decorin, ROCK1 no longer suppresses TSP-1 secretion; hence, there is enhanced movement of TSP-1-containing vesicles to the cell surface for its secretion and consequent angiogenesis inhibition.
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