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Shuji Mizumoto and Kazuyuki Sugahara Glycosaminoglycans are functional ligands for receptor for advanced glycation end-products in tumors The FEBS Journal 280

Version of Record online: 24 FEB 2013 | DOI: 10.1111/febs.12156

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Glycosaminoglycans attached to proteoglycans at the surface of tumor cells play key roles in malignant transformation and metastasis. Receptor for advanced glycation end-products (RAGE) expressed in lung was identified as a functional receptor for glycosaminoglycans expressed at the tumor cell surface. Hence, RAGE and glycosaminoglycans are potential targets of drug discovery for pulmonary metastasis.

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