Tsutomu Fujimori, Yukiko Kamiya, Kazuhiro Nagata, Koichi Kato and Nobuko Hosokawa Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsin variant FEBS Journal 280
Mammalian XTP3-B is an endoplasmic reticulum (ER)-resident lectin that contains two mannose 6-phosphate receptor homology (MRH) domains, which recognize sugar moieties, and is involved in ER-associated degradation (ERAD). XTP3-B did not enhance the degradation of misfolded glycoproteins, but instead inhibited the degradation of NHK bearing M9 oligosaccharides, unlike its homologue OS-9. We propose that XTP3-B acts as a negative regulator of ERAD.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf