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Alan C. Rapraeger Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R–αvβ3 integrin complex in tumorigenesis and angiogenesis FEBS Journal 280

Article first published online: 24 FEB 2013 | DOI: 10.1111/febs.12160

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An extracellular docking site in the matrix receptor syndecan-1 (Sdc1) captures the αVβ3 and αVβ5 integrins along with the insulin-like growth factor 1 receptor (IGF1R), clustering and activating the receptors at sites of matrix adhesion in tumor cells and activated endothelial cells. This minireview describes this mechanism and its disruption by synstatin, a peptide mimetic of the syndecan docking site.

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