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Christina J. Malavaki, Andreas E. Roussidis, Chrisostomi Gialeli, Dimitris Kletsas, Theodore Tsegenidis, Achileas D. Theocharis, George N. Tzanakakis and Nikos K. Karamanos Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells The FEBS Journal 280

Version of Record online: 27 FEB 2013 | DOI: 10.1111/febs.12163

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PDGF/PDGF-R-mediated signaling axis is highly associated with cancer progression. The regulatory role of PDGF-R in breast cancer is highlighted as imatinib, a specific PDGF-tyrosine kinase inhibitor, exerts an inhibitory effect on cancer cell proliferation, invasion and migration as well as HS-proteoglycans expression. Imatinib may be of a potential therapeutic usefulness in breast cancer regimes.

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