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Marta Ferraroni, Irene Matera, Sibylle Bürger, Sabrina Reichert, Lenz Steimer, Andrea Scozzafava, Andreas Stolz and Fabrizio Briganti The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate The FEBS Journal 280

Version of Record online: 28 FEB 2013 | DOI: 10.1111/febs.12173

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Salicylate 1,2-dioxygenase (SDO) from Pseudaminobacter salicylatoxidans BN12, an iron(II) class (III) ring-cleaving dioxygenase, is an unusual gentisate dioxygenase which converts in addition to gentisate also various monohydroxylated substrates. The structural characterization of the G106A SDO mutant, that converts only gentisate behaving like a ‘conventional’ gentisate dioxygenase, showed that salicylate bind to the mutant in an unproductive conformation

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