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Shany Koren and Mohamed Bentires-Alj Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors FEBS Journal 280

Article first published online: 1 MAR 2013 | DOI: 10.1111/febs.12175

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The phosphoinositide 3-kinase (PI3K) signaling pathway is frequently deregulated in human cancer. PIK3CA, the gene encoding the catalytic subunit p110α of PI3K, is mutated in ~30% of breast cancers. Here, we describe current mouse models harboring the hotspot mutation PIK3CA H1047R in the mammary gland and discuss differences in tumor latency and pathogenesis.

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