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Kulwant Singh and F. Jeffrey Dilworth Differential modulation of cell cycle progression distinguishes members of the myogenic regulatory factor family of transcription factors The FEBS Journal 280

Version of Record online: 8 MAR 2013 | DOI: 10.1111/febs.12188

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Myogenic regulatory factors (MRFs - MyoD, Myf5, Myogenin, and MRF4) are key transcription factors that regulate gene expression that establish the skeletal muscle cell fate. Here, we discuss the current literature concerning the role of MRFs in modulating cell cycle progression, and define Myogenin expression as a “point of no return” for establishing permanent cell cycle exit during muscle differentiation.

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