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Ruoyan Xu, Timothy R. Rudd, Ashley J Hughes, Giuliano Siligardi, David G. Fernig and Edwin A. Yates Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network FEBS Journal 280

Article first published online: 13 MAR 2013 | DOI: 10.1111/febs.12201

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Analysis of the signalling abilities of combinations of fibroblast growth factor (FGF) subfamilies 1–9 with FGF receptors and heparin co-receptor, revealed a core network of four FGF receptors. An ancient three membered network was evident, which evolved to four members at the divergence of FGF-21, -4 and -9 from the FGF-8 subfamily, increasing four-fold the available signaling options.

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