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Maria Pellegrini, Laure Willen, Mai Perroud, Dennis Krushinskie, Kathy Strauch, Hernan Cuervo, Eric S. Day, Pascal Schneider and Timothy S. Zheng Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions The FEBS Journal 280

Version of Record online: 18 MAR 2013 | DOI: 10.1111/febs.12206

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TWEAK and Fn14 are members of the TNF ligand and receptor super-families. Here we report how human and Xenopus Fn14 share a common tertiary fold and binding interface to TWEAK, despite the low sequence homology. We characterize the determinants for Fn14 binding to human TWEAK and discuss how cysteine-rich domains of TNF receptor superfamily have evolved over time.

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