E-mail a Wiley Online Library Link

Maren Eckey, Florian Kraft, Robert Kob, Niko Escher, Mohammad Asim, Heike Fischer, Marie K. Fritsche, Christian Melle and Aria Baniahmad The corepressor activity of Alien is controlled by CREB-binding protein/p300 The FEBS Journal 280

Version of Record online: 18 MAR 2013 | DOI: 10.1111/febs.12211

Thumbnail image of graphical abstract

Gene silencing by transcriptional repressors is mediated in part by corepressors. Here, we show that the corepressor Alien binds in vivo and in vitro to the coactivator CBP/p300. The interaction with these histone acetyltransferases leads to acetylation of Alien and functionally to reduced Alien-mediated transcriptional silencing. The data indicate how silencing function is modulated by post-translational modification.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field