Maren Eckey, Florian Kraft, Robert Kob, Niko Escher, Mohammad Asim, Heike Fischer, Marie K. Fritsche, Christian Melle and Aria Baniahmad The corepressor activity of Alien is controlled by CREB-binding protein/p300 FEBS Journal 280
Gene silencing by transcriptional repressors is mediated in part by corepressors. Here, we show that the corepressor Alien binds in vivo and in vitro to the coactivator CBP/p300. The interaction with these histone acetyltransferases leads to acetylation of Alien and functionally to reduced Alien-mediated transcriptional silencing. The data indicate how silencing function is modulated by post-translational modification.
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