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Maren Eckey, Florian Kraft, Robert Kob, Niko Escher, Mohammad Asim, Heike Fischer, Marie K. Fritsche, Christian Melle and Aria Baniahmad The corepressor activity of Alien is controlled by CREB-binding protein/p300 FEBS Journal 280

Article first published online: 18 MAR 2013 | DOI: 10.1111/febs.12211

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Gene silencing by transcriptional repressors is mediated in part by corepressors. Here, we show that the corepressor Alien binds in vivo and in vitro to the coactivator CBP/p300. The interaction with these histone acetyltransferases leads to acetylation of Alien and functionally to reduced Alien-mediated transcriptional silencing. The data indicate how silencing function is modulated by post-translational modification.

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