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Kristin V. T. Engebretsen, Ida G. Lunde, Mari E. Strand, Anne Waehre, Ivar Sjaastad, Henriette S. Marstein, Biljana Skrbic, Christen P. Dahl, Erik T. Askevold, Geir Christensen, Johannes L. Bjørnstad and Theis Tønnessen Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli The FEBS Journal 280

Version of Record online: 2 APR 2013 | DOI: 10.1111/febs.12235

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Lumican was increased in the failing heart of mice and men. In vitro cyclic mechanical stretch and inflammation induced lumican expression and protein secretion from cardiac fibroblasts. Moreover, increased lumican in cardiac fibroblasts induced expression of molecules important for cardiac remodeling and fibrosis, suggesting a role for lumican in heart failure development.

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