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Rong Li, Zheng Gong, Chang Pan, Di-Dong Xie, Jun-Yi Tang, Min Cui, Yun-Fei Xu, Wei Yao, Qi Pang, Zhi-gang Xu, Min-yong Li, Xiao Yu and Jin-Peng Sun Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase The FEBS Journal 280

Version of Record online: 3 MAY 2013 | DOI: 10.1111/febs.12275

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After EGF stimulation, PPM1A negatively regulated ERK phosphorylation at early time points. Biochemical results proved the direct association between PPM1A and phospho-ERK. Further kinetic studies identified the interaction between the R186 of PPM1A and the E203 and pY204 of phospho-ERK as a hot-spot for PPM1A/phospho-ERK interaction.

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