Chao Ren, Roshani Patel and Colin Robinson Exclusively membrane-inserted state of an uncleavable Tat precursor protein suggests lateral transfer into the bilayer from the translocon The FEBS Journal 280
Protein transport to the periplasm by the Tat pathway is directed by cleavable signal peptides. A mutated, uncleavable variant causes the precursor protein to remain embedded in the plasma membrane with the mature domain facing the periplasm. There is no evidence for complete transport, data suggesting that the substrate is released laterally from the translocon during transport.
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