Kimberly M. Maize, Carston R. Wagner and Barry C. Finzel Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily FEBS Journal 280
The histidine triad proteins (HITs) constitute a large and ubiquitous superfamily of nucleotide hydrolases. The human nucleotide binding proteins (hHints) are a distinct class of HITs noted for their acyl-AMP hydrolase and phosphoramidase activity. The first crystal structures of hHint2 with and without bound adenosine monophosphate are here described. The differences between hHint2 and known HIT-family protein structures are discussed.
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