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Jennifer Doig, Lowri A. Griffiths, David Peberdy, Permphan Dharmasaroja, Maria Vera, Faith J. C. Davies, Helen J. Newbery, David Brownstein and Catherine M. Abbott In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy The FEBS Journal 280

Version of Record online: 23 OCT 2013 | DOI: 10.1111/febs.12554

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Translation factor eEF1A2 is expressed specifically in neurons and muscle; null mutant (wasted) mice develop early onset neurodegeneration. Correction of eEF1A2 levels specifically in muscle fails to correct this phenotype. Markers of muscle atrophy are upregulated at the RNA but not the protein level in wasted mice, providing the first in vivo evidence for the role of eEF1A2 in translation.

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