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Y. Molero, C. Gumpert, E. Serlachius, P. Lichtenstein, H. Walum, D. Johansson, H. Anckarsäter, L. Westberg, E. Eriksson and L. Halldner A study of the possible association between adenosine A2A receptor gene polymorphisms and attention-deficit hyperactivity disorder traits Genes, Brain and Behavior 12

Article first published online: 7 MAR 2013 | DOI: 10.1111/gbb.12015

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When examining the relationship between adenosine A2A receptor (ADORA2A) gene polymorphisms and ADHD traits in a population-based sample of 1747 twins, results showed nominal associations between ADHD traits and three SNPs in the ADORA2A gene: rs3761422, rs5751876 and rs35320474. For one of the SNPs, rs35320474, results remained significant after correction for multiple comparisons. These results indicate the possible involvement of the ADORA2A in ADHD traits, a plausible notion as adenosine plays a role in ADHD-related neurobiological mechanisms such as dopamine neurotransmission and regulation of alertness. However, these results should be viewed as preliminary and more studies replicating the present results are warranted before this association can be confirmed.

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