W. Z. Amaral, G. R. Lubach, A. J. Bennett and C. L. Coe Inflammatory vulnerability associated with the rh5-HTTLPR genotype in juvenile rhesus monkeys Genes, Brain and Behavior 12
Carriers of the short rh5-HTTLPR allele evidenced a higher neutrophil-to-lymphocyte ratio in blood than their LL counterparts while in undisturbed housing conditions, indicative of an aroused state even in the absence of disturbance. In addition, S carriers underwent greater inhibition of cellular IL-6 responses to LPS stimulation after rehousing with an unfamiliar monkey. The inhibitory effect of stress remained evident in S-carriers even after adjusting for the number of mononucleocytes in circulation.
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