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E. Kádár, G. Huguet, L. Aldavert-Vera, I. Morgado-Bernal and P. Segura-Torres Intracranial self stimulation upregulates the expression of synaptic plasticity related genes and Arc protein expression in rat hippocampus Genes, Brain and Behavior 12

Version of Record online: 20 AUG 2013 | DOI: 10.1111/gbb.12065

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This report outlines three major observations regarding the molecular effects of ICSS memory-facilitative treatment in rat hippocampus. A single LH-ICSS session causes: (a) increases in the expression of IEGs related to synaptic plasticity and to learning and memory processes after 4.5 h; (b) the regulation of a subset of CREB family-dependent genes (including c-Fos, Arc, Bdnf, Ptgs-2, Crem and Icer) in a time-dependent manner following treatment administration; and (c) a significant induction, 4.5 h after administration, of Arc protein expression in CA1 and DG hippocampal subfields, revealing that ICSS specifically upregulates an effector protein related to morphological changes that underlie the synaptic modification involved in memory consolidation processes.

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