Yanhong Zhou, Sharon K. Michelhaugh, Carl J. Schmidt, Jun S. Liu, Michael J. Bannon and Zhicheng Lin Ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects Addiction Biology 19
Article first published online: 26 OCT 2011 | DOI: 10.1111/j.1369-1600.2011.00391.x
This study investigated the correlation between seven markers throughout hDAT and its mRNA levels in postmortem ventral midbrain tissues from 18 cocaine abusers and 18 strictly matched drug-free controls in the African-American population. We show that one major haplotype with the same frequency in cocaine abusers versus drug-free controls displays a 37.1% reduction of expression levels in cocaine abusers compared with matched controls (P = 0.0057). Findings suggest that varying hDAT activity is attributable to both genetics and cocaine abuse.
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