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Takenao Koseki, Akihiro Mouri, Shizuka Suzuki, Azusa Nakajima, Takayoshi Mamiya, Yijin Yan and Toshitaka Nabeshima Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice Addiction Biology 19

Article first published online: 19 JAN 2012 | DOI: 10.1111/j.1369-1600.2011.00425.x

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Methamphetamine (METH) dependence is becoming a serious problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.

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