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Pao-Huan Chen, Ming-Chi Huang, Ying-Ching Lai, Po-Yu Chen and Hsing-Cheng Liu Serum brain-derived neurotrophic factor levels were reduced during methamphetamine early withdrawal Addiction Biology 19

Version of Record online: 28 MAR 2012 | DOI: 10.1111/j.1369-1600.2012.00444.x

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In this study, we found that serum brain-derived neurotrophic factor (BDNF) levels were significantly and constantly lower in 59 human methamphetamine (METH) abusers during the first 3 weeks of withdrawal than those of the age- and sex-matched healthy controls. The greatest predictive validity for serum BDNF levels was provided by METH abuse itself but not other confounders in the multiple regression analysis. Findings suggest that METH abusers have a substantial BDNF down-regulation and possibly neuroprotective dysfunction after repetitive METH misuse.

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