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James J. Prisciandaro, Aimee L. McRae-Clark, Hugh Myrick, Scott Henderson and Kathleen T. Brady Brain activation to cocaine cues and motivation/treatment status Addiction Biology 19

Article first published online: 28 MAR 2012 | DOI: 10.1111/j.1369-1600.2012.00446.x

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The present study investigated the relationship between motivation to change cocaine use and cue-elicited brain activity in cocaine-dependent individuals using two conceptualizations of “motivation to change:” current treatment status and self-reported motivation to change. Thirty-eight cocaine dependent individuals completed an assessment and an fMRI cocaine cue-reactivity task. Both treatment-seeking (n=14) and motivated participants had lower activation to cocaine cues in a wide variety of regions in the frontal, occipital, temporal, and cingulate cortices relative to non-treatment-seeking and less motivated participants.

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