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Xaver Koenig, Michael Kovar, Stefan Boehm, Walter Sandtner and Karlheinz Hilber Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk Addiction Biology 19

Version of Record online: 28 MAR 2012 | DOI: 10.1111/j.1369-1600.2012.00447.x

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Ibogaine, an alkaloid derived from the African shrub Tabernanthe iboga, has shown promising anti-addictive properties in humans. Although not licensed as therapeutic drug, and despite evidence that ibogaine may disturb the rhythm of the heart, this alkaloid is currently used as an anti-addiction drug in alternative medicine. Here, we report that therapeutic concentrations of ibogaine reduce currents through human ether-a-go-go-related gene potassium channels. Thereby, we provide a mechanism by which ibogaine may generate life-threatening cardiac arrhythmias.

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