Bryon Adinoff, Michael D. Devous, Mark J. Williams, Thomas S. Harris, Susan E. Best, Hongyun Dong and Tanya Zielinski Differences in regional cerebral blood flow response to a 5HT3 antagonist in early- and late-onset cocaine-dependent subjects Addiction Biology 19
5-hydroxytryptamine 3 (5HT3) receptors modulate mesostriatal dopaminergic transmission and the 5HT3 antagonist ondansetron is effective in treating early-onset, but not late-onset, alcohol-dependent subjects. In this study, regional cerebral blood flow (rCBF) was assessed following the intravenous administration of ondansetron to early- (n=10) and late-onset (n=10) cocaine-dependent and 22 control participants. Group differences in rCBF were observed in the rostral anterior cingulate, posterior parahippocampus, anterior insula, and subthalamic nucleus. Age of cocaine use onset appears to be associated with serotonergic biosignatures.
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