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Andrea Cippitelli, Ruslan Damadzic, Carol Hamelink, Michael Brunnquell, Annika Thorsell, Markus Heilig and Robert L. Eskay Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective Addiction Biology 19

Article first published online: 13 APR 2012 | DOI: 10.1111/j.1369-1600.2012.00451.x

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Excessive ethanol use leads to impaired memory and cognition. Using a rat model of binge-like intoxication, we tested whether elevated corticosterone (Cort) levels contribute to the neurotoxic consequences of EtOH exposure. Rats were adrenalectomized (Adx) and implanted with cholesterol pellets, or cholesterol pellets containing Cort in order to achieve basal, medium, or high blood concentrations of Cort. Intragastric EtOH or an isocaloric control solution was given three times daily for 4 days to achieve blood alcohol levels ranging between 200 and 350 mg/dl.

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