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Erin S. Calipari, Mark J. Ferris, James R. Melchior, Kristel Bermejo, Ali Salahpour, David C. S. Roberts and Sara R. Jones Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations Addiction Biology 19

Article first published online: 28 MAR 2012 | DOI: 10.1111/j.1369-1600.2012.00456.x

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While methylphenidate and cocaine have similar inhibitory mechanisms of action at the dopamine transporter (DAT), the neurochemical consequences of i.v.self-administration of the two drugs are completely different. While a five-day history of cocaine self-administration selectively reduced cocaine potency at the DAT without affecting methylphenidate potency, methylphenidate self-administration selectively increased its own potency, as measured using voltammetry in the nucleus accumbens core. These findings suggest that the factors governing dopamine system adaptations are more complicated than simple DAT blockade.

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