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Alfredo Ghezzi, Harish R. Krishnan and Nigel S. Atkinson Susceptibility to ethanol withdrawal seizures is produced by BK channel gene expression Addiction Biology 19

Version of Record online: 27 JUN 2012 | DOI: 10.1111/j.1369-1600.2012.00465.x

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Alcohol withdrawal seizures are part of the symptomatology of severe alcohol dependence and are believed to originate from neural adaptations that counter the depressant effects of alcohol. When alcohol is withheld these pro-excitatory adaptations are uncovered and can be sufficient to generate a seizure. Using the Drosophila model organism, we demonstrate a central role for the BK-type Ca2+-activated K+ channel gene slo in the production of alcohol withdrawal seizures.

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