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Hiroki Ishiguro, Frank S. Hall, Yasue Horiuchi, Takeshi Sakurai, Akitoyo Hishimoto, Martin Grumet, George R. Uhl, Emmanuel S. Onaivi and Tadao Arinami NrCAM-regulating neural systems and addiction-related behaviors Addiction Biology 19

Article first published online: 11 JUL 2012 | DOI: 10.1111/j.1369-1600.2012.00469.x

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NrCAM has a role in substance abuse, possibly through its effects on behavioral traits that may affect addiction vulnerability, including novelty seeking, obsessive compulsion and responses to aversive or anxiety-provoking stimuli. Glutaminase appears to be involved in NrCAM-related molecular pathway, and a treatment with inhibitor of the enzyme PLG altered some mice's phenotypes in alcohol preference and in anxiety-like behavior. Thus, NrCAM could affect addiction-related behaviors via at least partially modulation of some glutamatargic pathways and neural function in brain.

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