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Lucas R. Watterson, Peter R. Kufahl, Natali E. Nemirovsky, Kaveish Sewalia, Megan Grabenauer, Brian F. Thomas, Julie A. Marusich, Scott Wegner and M. Foster Olive Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) Addiction Biology 19

Article first published online: 11 JUL 2012 | DOI: 10.1111/j.1369-1600.2012.00474.x

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The use and abuse of designer stimulant such as 3,4-methylenedioxypyrovalerone (MDPV), often sold as “bath salts”, has increased dramatically in recent years.

The present study reveals that MDPV supports robust intravenous self-administration behavior across a range of doses, leads to escalation of intake with prolonged access, and produces decreases in brain stimulation reward thresholds. Together, these results reveal potent rewarding and reinforcing effects of MDPV, suggestive of a high degree of addiction potential in humans.

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