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Rémi Martin-Fardon and Friedbert Weiss N-(2-methyl-6-benzoxazolyl)-N′-1,5-naphthyridin-4-yl urea (SB334867), a hypocretin receptor-1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking Addiction Biology 19

Article first published online: 26 JUL 2012 | DOI: 10.1111/j.1369-1600.2012.00480.x

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Orexins/hypocretins (Orx/Hcrt) are hypothalamic peptides that regulate a wide range of physiological processes that are recruited by drugs of abuse. We tested the effect of the specific Orx/Hcrt receptor-1 (Hcrt-r1) antagonist SB334867 on reinstatement elicited by ethanol-associated stimuli vs. stimuli associated with a conventional reinforcer (SuperSac, consisting of 3% glucose and 0.125% saccharin w/v). SB334867 dose-dependently reduced reinstatement induced by the ethanol- but not SuperSac-associated stimuli, supporting a differential role for Hcrt-r1 in mediating ethanol seeking vs. natural reward seeking.

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