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Tomohisa Mori, Mahardian Rahmadi, Kazumi Yoshizawa, Toshimasa Itoh, Masahiro Shibasaki and Tsutomu Suzuki Inhibitory effects of SA4503 on the rewarding effects of abused drugs Addiction Biology 19

Article first published online: 31 AUG 2012 | DOI: 10.1111/j.1369-1600.2012.00488.x

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Previous findings have shown that sigma-1 receptors are upregulated by the self-administration of methamphetamine, whereas sigma-1 receptor antisense can attenuate the behavioral effects of psychostimulants in rodents. We examined the effects of the selective sigma-1 receptor agonist SA4503 on the rewarding effects of abused drugs. SA4503 significantly attenuated the abused drug-induced place preference. These results suggest that SA4503 inhibits the rewarding effects of abused drugs.

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