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Paulina Janeczek, Rachel K. MacKay, Rodney A. Lea, Peter R. Dodd and Joanne M. Lewohl Reduced expression of α-synuclein in alcoholic brain: influence of SNCA-Rep1 genotype Addiction Biology 19

Article first published online: 13 SEP 2012 | DOI: 10.1111/j.1369-1600.2012.00495.x

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Genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify α-synuclein mRNA expression in autopsy samples of human prefrontal cortex. A marker (α-synuclein-repeat 1 microsatellite) associated with expression levels of the gene was genotyped in a Caucasian sample of 126 controls and 117 alcoholics. Alcoholics had greater frequencies of the shortest allele found (267 bp), which was associated with decreased expression of α-synuclein in prefrontal cortex.

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