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Price E. Dickson, Mellessa M. Miller, Tiffany D. Rogers, Charles D. Blaha and Guy Mittleman Effects of adolescent nicotine exposure and withdrawal on intravenous cocaine self-administration during adulthood in male C57BL/6J mice Addiction Biology 19

Article first published online: 17 SEP 2012 | DOI: 10.1111/j.1369-1600.2012.00496.x

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Studies of adolescent drug use show a pattern in which the use of tobacco precedes the use of other drugs and a positive relationship between adolescent tobacco use and later drug use. These observations have led to the hypothesis that a causal relationship exists between early exposure to nicotine and the later use of hard drugs such as cocaine.  Using male C57BL/6J mice, we tested the hypothesis that nicotine exposure in adolescence leads to increased intravenous self-administration (IVSA) of cocaine in adulthood.

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