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Stephen V. Mahler, Megan Hensley-Simon, Pouya Tahsili-Fahadan, Ryan T. LaLumiere, Charles Thomas, Rebecca V. Fallon, Peter W. Kalivas and Gary Aston-Jones Modafinil attenuates reinstatement of cocaine seeking: role for cystine–glutamate exchange and metabotropic glutamate receptors Addiction Biology 19

Article first published online: 27 SEP 2012 | DOI: 10.1111/j.1369-1600.2012.00506.x

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A primary effect of modafinil is to inhibit dopamine transport, which typically promotes rather than inhibits motivated behavior. We examined the role of nucleus accumbens extracellular glutamate and the group II metabotropic glutamate receptor (mGluR2/3) in modafinil effects. One group of rats was trained to self-administer cocaine for 10 days and extinguished, then given priming injections of cocaine to elicit reinstatement. Modafinil- inhibited reinstated cocaine seeking, and this effect was prevented by pre-treatment with bilateral microinjections of the mGluR2/3 antagonist LY-341495 (LY) into nucleus accumbens core. 

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