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Sukhwinder S. SOHAL, David REID, Amir SOLTANI, Chris WARD, Steven WESTON, H. Konrad MULLER, Richard WOOD-BAKER and Eugene H. WALTERS Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease Respirology 15

Article first published online: 12 JUL 2010 | DOI: 10.1111/j.1440-1843.2010.01808.x

In smokers and COPD patients, the reticular basement membrane is highly fragmented, with clefts containing cells staining for the proteolytic enzyme, matrix metalloproteinase-9 and the fibroblast protein, S100A4. There is double staining for S100A4 and the mesenchymal marker, vimentin. These are likely hallmarks of active epithelial mesenchymal transition.

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