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Alana Knapman, Sebastian F. Kaltwasser, Daniel Martins-de-Souza, Florian Holsboer, Rainer Landgraf, Christoph W. Turck, Michael Czisch and Chadi Touma Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism European Journal of Neuroscience 35

Version of Record online: 31 JAN 2012 | DOI: 10.1111/j.1460-9568.2011.07968.x

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Patients suffering from major depression have repeatedly been reported to have dysregulations in hypothalamus–pituitary–adrenal (HPA) axis activity along with deficits in cognitive processes related to hippocampal and prefrontal cortex (PFC) malfunction. Here, we utilized three mouse lines selectively bred for high (HR), intermediate, or low (LR) stress reactivity, determined by the corticosterone response to a psychological stressor, probing the behavioral and functional consequences of increased vs. decreased HPA axis reactivity on the hippocampus and PFC.

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