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K. Martinu, C. Degroot, C. Madjar, A. P. Strafella and O. Monchi Levodopa influences striatal activity but does not affect cortical hyper-activity in Parkinson’s disease European Journal of Neuroscience 35

Article first published online: 3 FEB 2012 | DOI: 10.1111/j.1460-9568.2011.07979.x

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Motor studies of Parkinson’s disease (PD) have shown cortical hypo-activity in relation to nigrostriatal dopamine depletion. Cognitive studies also identified increased cortical activity in PD. We have previously suggested that the hypo-activity/hyper-activity patterns observed in PD are related to the striatal contribution.

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