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Lalitha Madhavan, Brian F. Daley, Caryl E. Sortwell and Timothy J. Collier Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat European Journal of Neuroscience 35

Version of Record online: 14 MAR 2012 | DOI: 10.1111/j.1460-9568.2012.08019.x

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Neuroprotective and neurorescue effects after neural stem/precursor cell (NPC) transplantation have been reported, but the mechanisms underlying such phenomena are not well understood. Our recent findings in a rat Parkinson’s disease (PD) model indicate that transplantation of NPCs before a 6-hydroxydopamine (6-OHDA) insult can result in nigrostriatal protection which is associated with endogenous NPC proliferation, migration and neurogenesis.

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