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M. P. Noonan, N. Kolling, M. E. Walton and M. F. S. Rushworth Re-evaluating the role of the orbitofrontal cortex in reward and reinforcement European Journal of Neuroscience 35

Version of Record online: 4 APR 2012 | DOI: 10.1111/j.1460-9568.2012.08023.x

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The orbitofrontal cortex and adjacent ventromedial prefrontal cortex carry reward representations and mediate flexible behaviour when circumstances change. Here we review how recent experiments in humans and macaques have confirmed the existence of a major difference between the functions of the ventromedial prefrontal and adjacent medial orbitofrontal cortex (vmPFC/mOFC) on the one hand and the lateral orbitofrontal cortex (lOFC) on the other.

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