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Courtney M. Cameron and Regina M. Carelli Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose European Journal of Neuroscience 35

Article first published online: 22 FEB 2012 | DOI: 10.1111/j.1460-9568.2012.08024.x

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Distinct subsets of nucleus accumbens (NAc) neurons differentially encode goal-directed behaviors for natural vs. drug rewards, and the encoding of cocaine-seeking is altered following cocaine abstinence. Here, electrophysiological recording procedures were used to determine if the selective encoding of natural vs. cocaine reward by NAc neurons is: (i) maintained when the natural reinforcer is a highly palatable sweet tastant and (ii) altered by cocaine abstinence.

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