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Kristen N. Segovia, Merce Correa, Jessica B. Lennington, Joanne C. Conover and John D. Salamone Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training European Journal of Neuroscience 35

Article first published online: 30 MAR 2012 | DOI: 10.1111/j.1460-9568.2012.08036.x

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Nucleus accumbens is involved in several aspects of instrumental behavior, motivation and learning. Recent studies showed that dopamine (DA) release in the accumbens shell was significantly increased on the first day of training on a fixed ratio (FR) 5 schedule (i.e. the transition from FR1 to FR5) compared with those rats that continued FR1 training, even though the rats on their first day of FR5 training received less food reinforcement than rats continuing on the FR1 schedule.

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