Ana Pocivavsek, Hui-Qiu Wu, Greg I. Elmer, John P. Bruno and Robert Schwarcz Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood European Journal of Neuroscience 35
Article first published online: 19 APR 2012 | DOI: 10.1111/j.1460-9568.2012.08064.x
Levels of kynurenic acid (KYNA), an endogenous product of tryptophan degradation, are elevated in the brain and cerebrospinal fluid of individuals with schizophrenia (SZ). This increase has been implicated in the cognitive dysfunctions seen in the disease since KYNA is an antagonist of the α7 nicotinic acetylcholine receptor and the NMDA receptor, both of which are critically involved in cognitive processes and in a defining neurodevelopmental period in the pathophysiology of SZ.
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