Clarissa Schitine, Sara Xapelli, Fabienne Agasse, Laura Sardà-Arroyo, Ana P. Silva, Ricardo A. De Melo Reis, Fernando G. de Mello and João O. Malva Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem/progenitor cell cultures European Journal of Neuroscience 35
Ampakines are chemical compounds known to modulate the properties of ionotropic α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)-subtype glutamate receptors. The functional effects attributed to ampakines involve plasticity and the increase in synaptic efficiency of neuronal circuits, a process that may be intimately associated with differentiation of newborn neurons.
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