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M. J. Seiler, B. W. Jones, R. B. Aramant, P. B. Yang, H. S. Keirstead and R. E. Marc Computational molecular phenotyping of retinal sheet transplants to rats with retinal degeneration European Journal of Neuroscience 35

Version of Record online: 17 MAY 2012 | DOI: 10.1111/j.1460-9568.2012.08078.x

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Computational molecular phenotyping (CMP) was used to identify cells involved in the functional connections between retinal sheet transplants and degenerate rat retinas. Outer segments of transplant rods and cones were immunoreactive for opsin but nothing was seen in the host retina. Neuropil mingling occurred with absent glial barriers. CMP data indicate that horizontal cells and amacrine cells are involved in a novel circuit between transplant and host.

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