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Marco Ledri, Litsa Nikitidou, Ferenc Erdelyi, Gabor Szabo, Deniz Kirik, Karl Deisseroth and Merab Kokaia Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations European Journal of Neuroscience 36

Article first published online: 18 APR 2012 | DOI: 10.1111/j.1460-9568.2012.08080.x

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Cholecystokinin (CCK-) positive basket cells form a distinct class of inhibitory GABAergic interneurons, proposed to act as fine-tuning devices of hippocampal gamma-frequency (30–90 Hz) oscillations, which can convert into higher frequency seizure activity. Therefore, CCK-basket cells may play an important role in regulation of hyper-excitability and seizures in the hippocampus.

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