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Amber L. Martell, Jan-Marino Ramirez, Robert E. Lasky, Jennifer E. Dwyer, Michael Kohrman and Wim van Drongelen The role of voltage dependence of the NMDA receptor in cellular and network oscillation European Journal of Neuroscience 36

Version of Record online: 17 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08083.x

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Unraveling the mechanisms underlying oscillatory behavior is critical for understanding normal and pathological brain processes. Here we used electrophysiology in mouse neocortical slices and principles of nonlinear dynamics to demonstrate how an increase in the N-methyl-d-aspartic acid receptor (NMDAR) conductance can create a nonlinear whole-cell current–voltage (I–V) relationship which leads to changes in cellular stability.

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